Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee

Jeanne Palmer ¹, Jeannine S McCune ², Miguel-Angel Perales ³, David Marks ⁴, Joseph Bubalo ⁵, Mohamad Mohty ⁶, John R Wingard ⁷, Angelo Paci ⁸, Moustapha Hassan ⁹, Christopher Bredeson ¹⁰, Joseph Pidala ¹¹, Nina Shah ¹², Paul Shaughnessy ¹³, Navneet Majhail ¹⁴, Jeff Schriber ¹⁵, Bipin N Savani ¹⁶, Paul A Carpenter ¹⁷

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• PMID: 27481448

• DOI: 10.1016/j.bbmt.2016.07.013

Free article

Abstract

The Practice Guidelines Committee of the American Society of Blood or Marrow Transplantation (ASBMT) sought to develop an evidence-based review about personalizing busulfan-based conditioning. The Committee sought to grade the relevant published studies (June 1, 2008 through March 31, 2016) according to criteria set forth by the Steering Committee for Evidence Based Reviews from ASBMT. Unfortunately, the published literature was too heterogeneous and lacked adequately powered and sufficiently controlled studies for this to be feasible. Despite this observation, the continued interest in this topic led the Practice Guidelines Committee to develop a list of most frequently asked questions (FAQs) regarding personalized busulfan dosing. This "Considerations" document is a list of these FAQs and their responses, addressing topics of practical relevance to hematopoietic cell transplantation clinicians.

Keywords: Busulfan; Hematopoietic cell transplantation; Pharmacokinetics; Precision medicine; Therapeutic drug monitoring.

Copyright © 2016 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

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Publication types

• Practice Guideline

• Review

• Research Support, N.I.H., Extramural

MeSH terms

• Busulfan / administration & dosage*

• Hematopoietic Stem Cell Transplantation / methods

• Humans

• Myeloablative Agonists / therapeutic use

• Precision Medicine / methods*

• Transplantation Conditioning / methods*

Substances

• Myeloablative Agonists

• Busulfan

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